State Market Insights
By Category
All Pharmacies
192
Retail
107
Specialty
6
Hospital
12
LTC
63
MailOrder
1
Wholesale
1
Remote
2
Market Scale
Population
890,342
Density (all) /10k
2.15
Density (retail) /10k
1.19
Pharmacy Desert Counties
43
Avg. VigilScale™
61/100
Avg. Enrollment Age
15 yrs
Chain Mix
Solo (1)
56
Small Group (2–9)
23
Mid Chain (10–49)
50
Large Chain (50+)
28
Mega Chain
34
Special Designations
Independent
56
Sterile Compounding
3
Tele-Pharmacy
2
Government Owned
10
Non-Profit
6
Top Chains
LEWIS FAMILY
11%
WALMART
8%
WALGREENS
7%
South Dakota Pharmacy Landscape
🔒 Browse New Pharmacy Openings in South Dakota
Search recently enrolled pharmacies and filter by category
South Dakota Board of Pharmacy
State Regulator
Visit official state pharmacy board website
SD PDMP
Official Program Information
Prescription Drug Monitoring Program requirements and information
SD PDMP
Clinical Login
Look up patient prescription history before dispensing controlled substances
SD PDMP
Data Submission Portal
Submit prescription dispensing data to state monitoring database
Quick Facts
Key regulatory requirements and practice standards
Pharmacist-Technician Ratio
State regulations require a pharmacist-to-technician ratio of 1:3 (Retail) to maintain safe pharmacy operations.
Continuing Education
Pharmacists must complete 15 hrs annually of continuing education to maintain active licensure.
Technician Requirements
Pharmacy technicians in this state must meet the following requirement: Registration required.
Intern Supervision
Pharmacy intern supervision follows this standard: 1:1.
Remote Pharmacy
Remote pharmacy work and telepharmacy services are governed by these rules: Permitted.
Vaccine Authority
Pharmacist authority to administer vaccines: Protocol-based.
Regulatory Warnings
Compliance requirements and monitoring obligations
Pharmacist in Charge Notification
When a Pharmacist in Charge (PIC) changes, the pharmacy must notify the state board within the following timeframe: 10 days.
Prescription Monitoring Reporting
Prescription Monitoring Program (PMP) reporting requirements: Next business day.
PMP Query Requirements
Before dispensing controlled substances, pharmacists must check the Prescription Monitoring Program: Voluntary.
Board Inspection Focus
State pharmacy board inspections frequently focus on: SD has extensive 'Remote Dispensing' (Automated kiosks) in small towns..
Top Cities by Pharmacy Count
Largest pharmacy markets in South Dakota
Browse by County
All counties sorted by pharmacy count
Minnehaha County
197,742 pop · 35 retail · 1.77 density
Pennington County
110,386 pop · 14 retail · 1.27 density
Lincoln County
65,801 pop · 7 retail · 1.06 density
Codington County
28,402 pop · 7 retail · 2.46 density
Brown County
38,278 pop · 5 retail · 1.31 density
Davison County
19,966 pop · 5 retail · 2.50 density
Yankton County
23,311 pop · 4 retail · 1.72 density
Beadle County
19,089 pop · 3 retail · 1.57 density
Hughes County
17,812 pop · 4 retail · 2.25 density
Lawrence County
26,047 pop · 5 retail · 1.92 density
Meade County
29,970 pop · 3 retail · 1.00 density
Brookings CountyPharmacy Desert
34,631 pop · 1 retail · 0.29 density
Fall River County
7,079 pop · 1 retail · 1.41 density
Walworth County
5,317 pop · 1 retail · 1.88 density
Bennett County
3,391 pop · 1 retail · 2.95 density
Butte CountyPharmacy Desert
10,369 pop · 0 retail · 0.00 density
Charles Mix County
9,302 pop · 1 retail · 1.08 density
Clay CountyPharmacy Desert
14,953 pop · 1 retail · 0.67 density
Dewey County
5,275 pop · 1 retail · 1.90 density
Grant CountyPharmacy Desert
7,533 pop · 0 retail · 0.00 density
Lake CountyPharmacy Desert
11,207 pop · 0 retail · 0.00 density
Roberts CountyPharmacy Desert
10,242 pop · 0 retail · 0.00 density
Tripp County
5,607 pop · 1 retail · 1.78 density
Aurora CountyPharmacy Desert
2,590 pop · 0 retail · 0.00 density
Brule CountyPharmacy Desert
5,247 pop · 0 retail · 0.00 density
Clark CountyPharmacy Desert
3,837 pop · 0 retail · 0.00 density
Custer County
8,515 pop · 1 retail · 1.17 density
Day County
5,485 pop · 1 retail · 1.82 density
Deuel CountyPharmacy Desert
4,298 pop · 0 retail · 0.00 density
Douglas County
2,823 pop · 1 retail · 3.54 density
Edmunds CountyPharmacy Desert
4,014 pop · 0 retail · 0.00 density
Faulk CountyPharmacy Desert
2,140 pop · 0 retail · 0.00 density
Gregory CountyPharmacy Desert
3,983 pop · 0 retail · 0.00 density
Haakon CountyPharmacy Desert
1,755 pop · 0 retail · 0.00 density
Hutchinson County
7,401 pop · 1 retail · 1.35 density
Hyde County
1,319 pop · 1 retail · 7.58 density
Jerauld CountyPharmacy Desert
1,836 pop · 0 retail · 0.00 density
Kingsbury CountyPharmacy Desert
5,172 pop · 0 retail · 0.00 density
McCook CountyPharmacy Desert
5,714 pop · 0 retail · 0.00 density
Miner CountyPharmacy Desert
2,312 pop · 0 retail · 0.00 density
Moody County
6,346 pop · 1 retail · 1.58 density
Perkins CountyPharmacy Desert
2,970 pop · 0 retail · 0.00 density
Potter CountyPharmacy Desert
2,587 pop · 0 retail · 0.00 density
Spink CountyPharmacy Desert
6,355 pop · 0 retail · 0.00 density
Stanley CountyPharmacy Desert
2,979 pop · 0 retail · 0.00 density
Turner CountyPharmacy Desert
8,687 pop · 0 retail · 0.00 density
Union CountyPharmacy Desert
16,700 pop · 0 retail · 0.00 density
Bon Homme CountyPharmacy Desert
7,018 pop · 0 retail · 0.00 density
Buffalo CountyPharmacy Desert
1,859 pop · 0 retail · 0.00 density
Campbell CountyPharmacy Desert
1,534 pop · 0 retail · 0.00 density
Corson CountyPharmacy Desert
3,906 pop · 0 retail · 0.00 density
Hamlin CountyPharmacy Desert
6,196 pop · 0 retail · 0.00 density
Hand CountyPharmacy Desert
3,075 pop · 0 retail · 0.00 density
Hanson CountyPharmacy Desert
3,443 pop · 0 retail · 0.00 density
Harding CountyPharmacy Desert
1,176 pop · 0 retail · 0.00 density
Jackson CountyPharmacy Desert
2,838 pop · 0 retail · 0.00 density
Jones CountyPharmacy Desert
1,006 pop · 0 retail · 0.00 density
Lyman CountyPharmacy Desert
3,719 pop · 0 retail · 0.00 density
Marshall CountyPharmacy Desert
4,363 pop · 0 retail · 0.00 density
McPherson CountyPharmacy Desert
2,251 pop · 0 retail · 0.00 density
Mellette CountyPharmacy Desert
1,989 pop · 0 retail · 0.00 density
Oglala Lakota CountyPharmacy Desert
13,695 pop · 0 retail · 0.00 density
Sanborn CountyPharmacy Desert
2,373 pop · 0 retail · 0.00 density
Sully CountyPharmacy Desert
1,318 pop · 0 retail · 0.00 density
Todd CountyPharmacy Desert
9,353 pop · 0 retail · 0.00 density
Ziebach CountyPharmacy Desert
2,455 pop · 0 retail · 0.00 density
* Pharmacy Desert: fewer than 1 retail pharmacy per 10,000 residents, based on 2026 NPI and ROPA billing data.